Cyspera (Cysteamine) – Melasma treatment in Singapore

Cyspera (cysteamine) is a novel pigment corrector for conditions of hyperpigmentation such as melasma, post inflammatory hyperpigmentation and freckles.

Cysteamine is a natural metabolite of cysteine and is naturally present in our body. It is a compound that has been around for many years, but was difficult to store due to its volatility until recently when a pharmaceutical company based in Switzerland managed to stabilize its structure and make it available for use as a topical product.


How does Cyspera (Cysteamine) work?

Cyspera (cysteamine) works by reducing melanin production in the epidermis thus correcting these hyperpigmented marks.

What are the benefits of Cyspera (Cysteamine)?

A few benefits of Cyspera (cysteamine) over existing treatments for hyperpigmentation include:

  • Significant efficacy
  • Bio-compatible
  • Does not cause photosensitivity
  • Non cytotoxic, non mutagenic and non carcinogenic

What are the expected results does Cyspera (Cysteamine)?

In clinical studies, Cyspera (Cysteamine) improved pigmentary disorders in 90% of patients who used it.

It was also shown to reduce melanin in pigmented lesions by 67% over a period of 16 weeks.

Generally, results were seen within 2-3 months of once-daily application, and can subsequently be maintained on a twice weekly dose.

The efficacy is linked to the consistency and overall exposure to the medication over a period of time rather than daily duration of exposure.

Cyspera (Cysteamine) vs Hydroquinone?

Studies have so far demonstrated that Cyspera (Cysteamine) has a similar efficacy to hydroquinone.

The safety profile in long term use of Cyspera (Cysteamine) has so far been demonstrated to be safe, and in certain cases where melasma is resistant to hydroquinone, Cyspera (Cysteamine) has been shown to be effective.

Skin Pigmentation

How do I use Cyspera (Cysteamine)?

1. Do not wash your face before use.

Do not wash the skin before application. If necessary to wash, wait for one hour after washing before applying the cream.

2. Leave on for 15 minutes.

Apply a thin layer on your skin (a mild tingling may occur and can last up to 30 minutes). Leave on for 15 minutes

3. Wash off.

Remove the cream by washing the area with a gentle facial cleanser.

4. Moisturise

Moisturise the area. Maintain skin hydration during the day. Use UV protection.

Is Cyspera (Cysteamine) safe for breastfeeding or pregnant women?

There has been no studies conducted regarding the safety of Cyspera (Cysteamine) in pregnant or breastfeeding women. It should hence be avoided by pregnant/ breastfeeding women.

Are there any precautions I should take with Cyspera (Cysteamine)?

Avoid using cysteamine if you have a family history (close family member) suffers from vitiligo.

Keep out of reach of children

It is stored at room temperature

Does Cyspera (Cysteamine) have side effects?

Cyspera (Cysteamine) is a very safe medication. Side effects are generally mild and resolve on their own. 

These mild side effects include redness, dryness and possibly irritation of the skin.

A mild tingling sensation may occur immediately after application up to 30 minutes after application. This is normal and may happen in the first few days of using Cyspera (Cysteamine).

How can I minimize the side effects?

You can minimize the side effects of Cyspera (Cysteamine) by:

  • Avoid washing your face at least 1 hour before application
  • Avoid prolonged application time (keep to 15 minutes)
  • Avoid concomitant use of other medications unless advised otherwise by your doctor

How much is Cyspera (Cysteamine) in Singapore?

The price of Cyspera (Cysteamine) in Singapore costs between $250-$320.

At S Aesthetics Clinic, Cyspera is $272.50

Can Cyspera (Cysteamine) be used with other treatments?

In the treatment of hyperpigmentary conditions, there is no one-size-fits-all approach.

Treatments that can be combined with Cyspera (Cysteamine) include pigment lasers, sunscreen and UV protection and other non-medicated topical products.

Speak to your doctor to see which treatment will suit you best.

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